Lect3notes

Lect3notes - DNA to RNA: transcription & processing DNA...

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How is informational content expressed? RNA DNA to RNA: transcription & processing DNA to RNA: transcription & processing Ch.8 Ch.8 DNA vs RNA 1. Single stranded 2. ribose (2’OH) 3. u vs t 4. enzymatic 2 classes of RNA : - informational (rna polII) (rna-> protien) - functional (growing list) - tRNA: aa carriers (RNA PolIII) - rRNA: ribosome comp (RNA PolI) - snRNA: splicing mach. - miRNAs: gene regulation - siRNAs: genome integrity - rasiRNAs: heterochromatin - piRNAs: transposon silencing??
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Gene 1 Coding strand Gene 2 Coding strand How does Transcription occur ? • asymmetric • RNA synthesized in 5’ to 3’ direction • RNA Pol moves in the 5’ to 3’ direction Transcription : coding strand (non-template) non-coding (template) DNA to RNA: transcription & processing DNA to RNA: transcription & processing Ch.8 Ch.8 promoter
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1. Transcriptional Regulation - controlled by DNA regulatory regions a. promoter (consensus) b. Enhancers faster c. Silencer slow/stop 3. Production (RNA Pol I-III) DNA to RNA: transcription & processing DNA to RNA: transcription & processing Ch.8 Ch.8 Problems RNA Pol faces? 1. Regulation 2. Access 3. Production 4. Termination 2. DNA Access - controlled by chromosomal structure - histone modification- histone code - epigenetics 4. Termination
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4 phases a. Template recognition b. initiation c. elongation d. termination DNA to RNA: transcription & processing DNA to RNA: transcription & processing Ch.8 Ch.8 How does Transcription occur? a. template recognition (access)
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Lect3notes - DNA to RNA: transcription & processing DNA...

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