BB2920 Lect1F10

BB2920 Lect1F10 - WhatisGenetics studyofgenes Ch.1 Genotype Genetic constitution constitution DNA gene chromosome Environment genome transcriptome

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What is Genetics?   study of genes   understanding of heredity Genotype: Genotype: Phenotype: Phenotype: Environment Environment Genetics and the organism Genetics and the organism Ch.1 Ch.1 DNA gene organism chromosome genome mRNA mRNA transcriptome proteome proteins proteins cell Genetic Genetic constitution constitution Outward Outward manifestation manifestation of genotype of genotype
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Genetics and the organism Genetics and the organism Ch.1 Ch.1 What is heredity? - biological similarity of offspring and parents • What is basis of heredity? DNA – genome - ploidy n = haploid 2n = diploid homologous chromosomes • Similarity Identical - Why not identical? variation! (polymorphisms) - Identical means what? absence of variation - clonal Human genome – 3X109bp, >99% identical variation ~1-12million bp
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• Phenotypic traits can display variation WINGS discontinuous discontinuous EYE PIGMENT continuous continuous Genetics and the organism Genetics and the organism Ch.1 Ch.1 • What causes variation in nature? 1. Genes come in different forms = alleles alleles 2. Environmental impact 3. Random - “developmental noise” Examples of each???
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What is normal variation? wild type = “norm of reaction” mutant mutant = “outside norm of reaction” = “outside norm of reaction” Genetics and the organism Genetics and the organism Ch.1 Ch.1 Take Home: Take Home: variation exists and forms variation exists and forms basis for genetic analysis! basis for genetic analysis! Developmental noise = source of variation
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Genetic determination of phenotype Genetics and the organism Genetics and the organism Ch.1 Ch.1 Take Home: Take Home: variation exists and forms variation exists and forms basis for genetic analysis! basis for genetic analysis!
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This note was uploaded on 09/01/2010 for the course BB 10294 taught by Professor Politz during the Spring '10 term at WPI.

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BB2920 Lect1F10 - WhatisGenetics studyofgenes Ch.1 Genotype Genetic constitution constitution DNA gene chromosome Environment genome transcriptome

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