Lect4notes

Lect4notes - Gene Function: Activity Gene How do mutations...

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How do mutations affect the informational content How do mutations affect the informational content of a gene/protein? of a gene/protein? Mutations a. base changes - silent - missense - nonsense b. frameshifts - additions - deletions c. chromosomal anomalies - insertion - deletion - inversion - translocation Gene Function: Activity Gene Function: Activity
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Mutations and Ploidy a. recessive (b) - phenotype only observed in homozygote b / b Genotype name Phenotype + / + homozygote wild-type b / + b / b How do mutations affect gene function? How do mutations affect gene function? b. Dominant (C) - phenotype observed in heterozygote C / C + or C / + Genotype name Phenotype + / + homozygote wild-type C / + C / C * haplo-insufficient * haplo-insufficient * hemizygous hemizygous gene name allele Gene Function: Activity Gene Function: Activity
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. a. loss-of-function alleles: - - - How do mutations affect the informational content How do mutations affect the informational content
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This note was uploaded on 09/01/2010 for the course BB 10294 taught by Professor Politz during the Spring '10 term at WPI.

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Lect4notes - Gene Function: Activity Gene How do mutations...

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