3 NS Development

3 NS Development - OT 441 FOUNDATIONS OF OCCUPATION...

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OT 441: FOUNDATIONS OF OCCUPATION: NEUROSCIENCE Lecture 2: Mini Review
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Review Questions What ions/anions are in greater concentration intracellularly vs. extracellularly when looking at a neuron’s resting membrane potential? Name the 4 components of a neuron & what do they do? 1. _____________________________________ __ 2. _____________________________________ __
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Review Questions The most common type of synapse is: The “all or none” decision is made by:
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Review Questions Name 2 diseases of demyelination T Is this disease in the PNS or the CNS? T What kind of macroglia creates the myelin here? T Is there hope for regeneration?
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FOUNDATIONS OF OCCUPATION: NEUROSCIENCE Lecture 3: Development of the Nervous System
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Outline 1. Development of the neural tube a. Disorders of the neural tube 1. Development of the brain 2. 3. Supporting the brain a. Clinical Correlates
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Formation of the NS Two phases of the Embryonic Stage T Neural tube formation T Brain formation Embryo develops into 3 layers in this stage: T Endoderm T Mesoderm: Dermis, muscles, skeleton, excretory & circulatory systems T Ectoderm:
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Development of the Neural Tube (18 – 26 days) Arises from the neural plate T Neural plate: a thickening of the ectoderm on the surface of the embryo
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Development of the Neural Tube The edges of the neural plate fold to form neural groove (day 18) Mesoderm divides into cell clusters called somites.
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Development of the Neural Tube When the edges touch, the neural tube is formed (Day 21) T “Zips” up both rostrally and caudally, leaving ends open Cells adjacent to the tube develop into the neural crest. T Superior neuropore closes first and the inferior neuropore closes soon after
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Development of Neural Tube Tube differentiates into 2 concentric circles (by day 26) T Mantle layer: becomes gray matter of SC T Marginal layer: becomes white matter of SC Neural crest – separates into 2 columns T Become PNS
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Tube Grooves form on each side of the neural tube, separating the mantle layer into
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This note was uploaded on 09/02/2010 for the course OT 441 taught by Professor Stein during the Summer '10 term at USC.

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3 NS Development - OT 441 FOUNDATIONS OF OCCUPATION...

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