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Lec 17 Recovery - lecture

Lec 17 Recovery - lecture - OT 441 Foundations of ccupation...

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OT 441: Foundations of Occupation - Neuroscience Recovery!!
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Recovery vs. Sparing Factors influencing the potential for sparing or recovery The nature of damage Age Experience
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Why do people recover? 1. Redundancy 2. Resolution of diaschisis 3. Silent synapses 4. Sprouting 5. Denervation sensitivity 6. Synaptic hypereffectiveness 7. Functional reorganization of the brain 8. Activity-related Changes in NT release 9. Pharmacological interventions 10. Other, non-neurological reasons….
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NEUROPLASTICITY!!!! The ability of neurons to change their function, chemical profile or structure. This is essential for recovery from damage to the CNS.
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WHY????? Redundancy Resolution of Diaschisis: Functional standstill or abolition of electrical activity in areas surrounding or related to the damaged part of the system
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WHY????? Unmasking of silent synapses Sprouting: the regrowth of axons Collateral sprouting: Regenerative sprouting: Problems:
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WHY?????
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