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1-14 - OT 261(Physiology for Occupational Therapists Spring...

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1 OT 261 (Physiology for Occupational Therapists) Spring 2010 Today’s Topics General cell structure Functions of cellular constituents Cell-cell interaction/communication Function of proteins
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2 Structure of a Generalized Cell Structure determines function If structure is changed, so is function
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3 Fluid Mosaic Model Separates intracellular fluids from extracellular fluids Glycocalyx area abutting the cell that provides highly specific biological markers by which cells recognize one another contains glycoproteins and glycolipids
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4 Types of Membrane Proteins
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5 Functions of Membrane Proteins
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6 Functions of Membrane Proteins (cont.)
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7 Membrane Junctions Tight Junction “impermeable” junction that encircles the cell prevent molecules from passing between adjacent cells
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8 Membrane Junctions Desmosome anchoring junction scattered along the sides of cells provide strong attachments (like rivets)
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9 Membrane Junctions Gap junction a nexus that allows chemical substances to pass between cells great for cell-cell communication
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10 Passive Membrane Transport: Diffusion Simple diffusion – lipid-soluble substances Diffuse directly through the lipid bilayer Does not require ATP i.e. steroids Channel-mediated facilitated diffusion – lipid- insoluble substances Diffuse through channels created by proteins Does not require ATP i.e. water and small ions Both of these processes require a CONCENTRATION GRADIENT
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11 Passive Membrane Transport: Diffusion Carrier-mediated facilitated diffusion – large, lipid-insoluble molecules such as simple sugars Combine with protein carriers Only works if solute has concentration gradient Does not require ATP Binding of solute causes conformational change in protein carrier
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12 Effect of Membrane Permeability on Diffusion and Osmosis (if permeable to water and solute)
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13 Effect of Membrane Permeability on Diffusion and Osmosis (permeable only to water)
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14 Passive Membrane Transport: Filtration The passage of water and solutes through a membrane by hydrostatic pressure
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