GB.Translation_lodish_6e

GB.Translation_lodish_6e - A Quick Recap of Translation...

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1 1 Translational Control Mechanisms Roles of Proteins and Noncoding RNAs 2 A Quick Recap of Translation Initiation 3 4
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2 5 The Closed Loop Model of Translation Initiation 6 Protein-mediated Translational Regulation 7 Nature Rev. MCB 2: 521, 2001 Translational Regulation during Embryogenesis - I 8 Translational Regulation during Embryogenesis - II P Eg2 kinase Maskin
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3 9 Drosophila Embryogenesis Revisited: Spatial Distribution of Transcription Factors - I 10 Drosophila Embryogenesis Revisited: Spatial Distribution of Transcription Factors - II Smaug 11 Noncoding RNA-mediated Translational Regulation (and sometimes, mRNA degradation) 12 MicroRNAs: 22-25 nt Noncoding RNAs Bartel, Cell 116: 281-297, 2004 The founding members Animals Plants
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4 13 The Structures of Pri-miRNA Transcription Units Exonic miRNAs in coding or noncoding transcripts Intronic miRNAs in coding or noncoding transcripts Have 5’ cap and 3’ poly(A) tract Note: there can be more than one pri-miRNA contained within a single transcript 14
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GB.Translation_lodish_6e - A Quick Recap of Translation...

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