GB_RNA processing-lodish_6e

GB_RNA processing-lodish_6e - Harvey Lodish Arnold Berk...

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1 1 Molecular Cell Biology Sixth Edition Chapter 8: Post-Transcriptional Controls and Nuclear Transport Harvey Lodish • Arnold Berk • Paul Matsudaira • Chris A. Kaiser • Monty Krieger • Matthew P. Scott • Lawrence Zipursky • James Darnell 2 Processing of Eukaryotic Pre-mRNA 3 A Whole Bunch of Control Points for Gene Expression 4 Overview of mRNA Processing in Eukaryotes: Transcription is only the Beginning
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2 5 Heterogeneous Ribonucleoproteins Decorate Nascent Transcripts Lampbrush chromosome stained with MAb for hnRNPs 6 Many hnRNP Proteins Contain RRMs: β α β - β α β Structure RNP1 = K G F G F V X F R Y A Y RNP2 = L F V G N L I Y I K G M N C 7 Other RNA-binding Motifs Exist in RNABPs KH domain first found in hnRNP K 45 amino acids 3 β - sheets and 2 α -helices RGG box multiple Arginine-Glycine-Glycine repeats frequently found with KH domains 8 3’-End Formation: RNA Processing, Not Transcription Termination per se
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3 9 10 11 12
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4 13 14 Amazingly, mRNAs come from Noncontiguous Gene Sequences: Pre-mRNA Splicing 15 Consensus Sequences Surround the 5’ and 3’ Splice Sites 16 The Joining of Two Exons Requires Only Two Transesterification Reactions
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GB_RNA processing-lodish_6e - Harvey Lodish Arnold Berk...

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