BH.Fall2007.class2 - Chapters 17 and 18 Introduction: The...

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1 Introduction: The building blocks of the cytoskeleton Actin, actin dynamics, and actin-binding proteins Intermediate filaments Myosins motor proteins Myosins-powered movements Actin-directed movement Cell migration Chapters 17 and 18 Microtubules Kinesins and dyneins; structure and function Mitosis Myosins: Motor proteins that ‘walk’ along actin filaments Motor proteins are enzymes that couple the hydrolysis of ATP to a conformational change Kinesin and dynein: Motor proteins that ‘walk’ along microtubules Structure of myosin II Myosin: the actin motor protein All myosins have head, neck, and tail domains with distinct functions Figure 18-20 XVIII ~40 genes minus end QuickTime™ and a Sorenson Video 3 decompressor are needed to see this picture. The Way Things Move: Looking Under the Hood of Molecular Motor Proteins Ronald D. Vale and Ronald A. Milligan Science, 2000 288:80-95 http://valelab.UCSF.edu/index.html
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2 The Way Things Move: Looking Under the Hood of Molecular Motor Proteins Ronald D. Vale and Ronald A. Milligan Science, 2000 288:80-95 Myosins have diverse, well-defined, functions How do motor proteins work? Chemical Cycle MM - A T P M-ADP-Pi M-ADP 1. 2. 3. 4. The American Society for Cell Biology iBioSeminars, Ron Vale QuickTime™ and a Video decompressor are needed to see this picture. The movement of myosin along actin filaments The Way Things Move: Looking Under the Hood of Molecular Motor Proteins Ronald D. Vale and Ronald A. Mil igan Science, 2000 288:80-95 Head-motor Lever arm Converter Domain “switch loop” “Power stroke” Linker region The length of the myosin II neck domain determine the rate of movement
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3 The processivity of myosins The movment of Myosin V QuickTime™ and a
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This note was uploaded on 09/02/2010 for the course BME 314 taught by Professor Frey during the Spring '08 term at University of Texas at Austin.

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BH.Fall2007.class2 - Chapters 17 and 18 Introduction: The...

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