Lecture 1-5 - BIO 325 Genetics Lecture 1 ~ 5 MWF 9:00 10:00...

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BIO 325 Genetics – Lecture 1 ~ 5 MWF 9:00 – 10:00 AM Instructor: Sibum Sung TA: Brett Zografos
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TEXT BOOKS Genetics (From Genes to Genomes); 3 rd edition by Hartwell et al. Study Guide/Solutions Manual by Debra Nero You will need both !
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Grades - see course syllabus for detail 4 Quiz scores (5 will be given during class) 4 Homework scores (5 will be given) 2 one hour exams (3 will be given) 1 two hour comprehensive final May 19. 9:00-11:00 AM
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Web All course material will be posted on Blackboard You will find it useful to use publisher’s web site www.mhhe.com/hartwell3
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Readings & Problem sets Under the course schedule, each lecture has Chapter number. 1.Before class: read corresponding chapter(s). 2.After class: work on problem sets from corresponding chapters(s) Quiz will be based on problem sets; so you better work on those. Homework you should provide your own answer. Need help? : I and Brett will help you!
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Genetics - The study of biological information
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Genetics - The study of biological information The study of heredity The study of biological variation
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Genetics - History 1866 Mendel’s paper published 1900 Rediscovery of Mendel 1941 One gene-one enzyme hypothesis 1944 Discovery that DNA is the genetic material 1953 Structure of DNA solved 1954 First case of autosomal linkage in humans 1965 Genetic code deciphered 1968 First assignment of a human gene to a specific autosome Ten cases of autosomal linkage in humans 1973 Advent of recombinant DNA 2000 Human genome sequenced
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yellow P green X all yellow self-fertilize 6022 yellow : 2001 green F 1 (yellow yellow) X F 2 Genetics - Mendel’s 3:1 Note: We will come back to the Mendelian genetics at the end of semester
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Genetics - in the news
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Genetics - in the news
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Genetics What is the mechanism of heredity? What is the biochemical and molecular basis for the function of genes? What is the genetic basis of evolutionary change in natural populations?
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Genetics DNA molecules encode the biological information fundamental to all life forms. Biological function emerges primarily from protein molecules. Complex biological systems emerge from the functioning of regulatory networks that specify the behavior of genes. All living forms are closely related. Genomes are modular, allowing rapid evolution. Genetic techniques permit dissection of biological complexity.
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Diversity of living organisms on earth
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Diversity of living organisms on earth - but information is in the same molecule
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Four bases – G (guanine), A (adenine), T (thymine), and C (cytosine) are the nucleotide building block of DNA DNA is a double stranded helix composed of A-T and G-C complementary bases. Order of nucleotide sequences determines which proteins are synthesized, as well as when and where the synthesis occurs. Information in DNA molecule generates diversity
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DNA resides within cells packaged as units called chromosomes The entire collection of chromosomes in each cell of an organism is called a genome .
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