Lecture 28 - Epigenetics; DNA, RNA and Histones Outline...

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Epigenetics; DNA, RNA and Histones
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Outline Historical Background Mechanisms of Epigenetics DNA methylation Histone codes non coding RNA More unknown
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First use and re-define Conrad Waddington (1942) - the study of the relationship between genotype and phenotype
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First use and re-define Robin Holliday (1987) - the changes in gene activity during development are generally referred to as epigenetic
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First use and re-define Robin Holliday (1987) - the changes in gene activity during development are generally referred to as epigenetic Heritable changes?
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First use and re-define Robin Holliday (1994) - Nuclear inheritance which is not based on differences in DNA sequence
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First use and re-define 90’s Heritable changes which are not explained by Mendelian genetics
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Non-Mendelian Genetics? Mendel’s Experiment on Hieracium (Hawkweed) was non-Mendelian - parthenogenesis (Nogler, 2006)
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First use and re-define Wu & Morris (2001) - the study of changes in gene function that are mitotically and/or meiotically heritable and that do not entail a change in DNA sequence
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Chromatin history Walther Flemming coined term “chromatin” ca 1880 Described mitosis Subsequent work revealed that chromatin is composed of nucleic acid and protein Mendel rediscovered ca 1900
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DNA is genetic material (Gonick & Wheelis, 1983)
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DNA structure (1953) Hershey-Chase (1952) DNA is genetic material
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Hotchkiss (1948)
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This note was uploaded on 09/02/2010 for the course BIO 325 taught by Professor Saxena during the Spring '08 term at University of Texas.

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Lecture 28 - Epigenetics; DNA, RNA and Histones Outline...

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