This preview shows pages 1–2. Sign up to view the full content.
This preview has intentionally blurred sections. Sign up to view the full version.View Full Document
Unformatted text preview: Problem Set 1 for BIBC 100 Fall 2009 Note: You will not be able to answer all of the questions until after lecture on 10/5/09 1a) What do the pK values in the chart below tell you? Compound pK 1 pK 2 pK R pI Glycine 2.34 9.60 5.97 Glutamate 2.19 9.67 4.25 3.22 Arginine 2.17 9.04 12.48 10.76 The pK values for three amino acids are shown. The pK1 value is fairly close to 2 for all three aa, this is the pH at which the carboxyl group in the aa is equally deprotonated, and the molecule carries a net positive charge. The pK2 values are in the 9-10 pH range, and is representative of the pH at which the carboxyl group is deprotonated, the amino group in the aa is equally deprotonated, and the molecule carries a net negative charge. The pKR value is the point at which a side chain group is equally deprotonated. Note that here is no pKR value for glycine, since its side chain is simply a highly stable hydrogen. The pI stands for the Isoelectric point. At this pH, The concentration of acid is equal to base, and thus stable hydrogen....
View Full Document
This note was uploaded on 09/04/2010 for the course BIBC 100 taught by Professor Nehring during the Fall '07 term at UCSD.
- Fall '07