moritz4-1 - Bio1B Evolution 4 Last lecture: More history -...

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1 Bio1B Evolution 4 Last lecture: More history - Darwin+Mendel => the neodarwinian synthesis Mechanisms of evolution: – Evolution in populations - population genetics – Allele, genotype and phenotype frequencies – Predicting genotype freq’s: Hardy (Castle) Weinberg Equilibrium Application: Null model for evolution Today Predicting genotype freq’s: Hardy (Castle) Weinberg Equilibrium – Application: Predicting heterozygote frequencies for recessive traits Evolutionary processes Sampling effects => “genetic drift” – Relevance in evolution - loss of variation, bottlenecks Mutation as the ultimate source of variation; effects on fitness Selection – fitness – Forms and consequences 2 Applications of HWE • A null model for evolution – Deviations from expected proportions indicate something interesting - but what? • Predicting frequency of heterozygotes for recessive alleles, e.g. cystic fibrosis
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moritz4-1 - Bio1B Evolution 4 Last lecture: More history -...

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