moritz5-1 - Bio1B Evolution 5 L a s t le c t u r e :...

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1 Bio1B Evolution 5 Last lecture : Predicting genotype freq’s: Hardy (Castle) Weinberg Equilibrium – Application: Predicting heterozygote frequencies for recessive traits Evolutionary processes Sampling effects => “genetic drift” – Relevance in evolution - loss of variation, bottlenecks Today Evolutionary processes Mutation as the ultimate source of variation; effects on fitness Migration (as gene flow ) Selection – Fitness – Forms of selection – Heterozygote advantage - eg. sickle cell anaemia – Directional selection - eg. coat color in mice; genome signatures, experimental evidence 2 Mutations - forms Fig. 17.22 Hbb A Hbb S Fig 18.8 Regulation Coding Changes in : Coding sequence Gene regulation Gene copy number structure Exons -> mRNA -> aa 3 Agouti melanistic mutations: Recessive [regulatory Mc1r Melanistic mutations Dominant [structural] X
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moritz5-1 - Bio1B Evolution 5 L a s t le c t u r e :...

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