Drugs129spr10 - Drugs and Addiction (Chapter 15 plus) Drugs...

Info iconThis preview shows pages 1–14. Sign up to view the full content.

View Full Document Right Arrow Icon
Drugs and Addiction (Chapter 15 plus)
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Drugs What is a drug? What defines addiction? What is common to all addictive substances? Which of the addictive substances is most addictive and most dangerous?
Background image of page 2
What is a drug? What is a psychoactive drug?
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Pharmacokinetics Drug Administration- Routes ingestion injection inhalation Drug Penetration of the CNS Metabolism
Background image of page 4
Method of Administration Affects Blood Concentration and Addictive Potential
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Drug Addiction: Characteristics Drug addiction involves Persistent drug-taking Tolerance Withdrawal
Background image of page 6
Historical Perspective NEURAL SUBSTRATES OF REWARD Discovery of Brain Stimulation Reward Hypothesis of Reward Neuroanatomical Substrates of Reward Addiction
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Setup for demonstrating BSR (brain stimulation reward) Carries electrical current to brain Depression of bar activates stimulator stimulator
Background image of page 8
Drugs of abuse activate and/or modify the brain’s reward circuitry. Repeated exposure produces long-lasting adaptations.
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
The principle component is the nucleus accumbens . The nucleus accumbens consists of a ventral shell and dorsal core . The shell region is the target of the mesolimbic dopamine system. Nucleus Accumbens in Reward
Background image of page 10
Addiction Addiction is characterized by a compulsive need to readminister a drug. The dopamine reward system, including the nucleus accumbens, has been implicated in addiction. Addiction is the result of complex physical and environmental variables, making it extremely challenging to treat.
Background image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Drug Addiction Physical dependence refers to an adaptive state in which Increased experience with the drug leads to reduced drug action (tolerance ) Cessation of drug-taking leads to intense physiological disturbances (withdrawal ) Withdrawal symptoms are typically the opposite of the normal drug action Heroin is an example of a physically addictive drug Psychological dependence is a condition in which Taking a drug produces a pleasurable state A person is motivated to take the drug in order to maintain a pleasurable state or to avoid discomfort
Background image of page 12
Withdrawal Withdrawal symptoms that accompany drug- taking are usually aversive
Background image of page 13

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 14
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 41

Drugs129spr10 - Drugs and Addiction (Chapter 15 plus) Drugs...

This preview shows document pages 1 - 14. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online