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Xue abstract fall09 - and its structural analog(NiCR-2H...

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CHEMISTRY Departmental Seminar Prof. Liang Xue University of the Pacific, Stockton, CA Investigation on Interactions between Small Molecules and DNA Lesions The DNA that makes up our genes under physiological conditions is constantly exposed to a large number of endogenous and exogenous agents (e.g. free radicals and other electrophiles), resulting in strand breaks, as well as modified nucleotides (lesions) within intact strands of the biopolymer. If not repaired, DNA lesions can be genotoxic and have been implicated in aging and diseases such as cancer. We are interested in studying molecules that can produce DNA lesions and molecules that can react with specific DNA lesions. In this talk, we will highlight our recent work on DNA lesions by introducing two different projects. First, we have investigated the interactions of NiCR
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Unformatted text preview: and its structural analog (NiCR-2H) with synthetic and native DNA and hope to use the information to address a previous observation that NiCR-2H is more cytotoxic toward MCF-7 cancer cells than NiCR. Second, we have synthesized molecules that can specifically form adducts with 7,8-dihydro-8-oxo-guanosine (8-oxodG) present in DNA G-quadruplex structures in the presence of one-electron oxidants. These molecules are expected to inhibit human telomerase activity. Tuesday, November 10, 2009, 4:30 PM Duncan Hall 135 For more information: email or phone Prof. Annalise Van Wyngarden at [email protected] or 408-924-5282...
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