CheruzelSJabstract-1-2 - last thirty years and are still...

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CHEMISTRY Departmental Seminar Prof. Lionel Cheruzel Metalloenzymes, dioxygen and synthetic metal complexes: an overview Most of the first row transition metals are commonly found as natural constituents of proteins. Nature has been able to tune and use the special properties of metal ions to perform a wide variety of functions associated with life processes. The first part of the talk will introduce three classes of metalloproteins based on the interaction of their metal ions with dioxygen. Metalloproteins belonging to the first class are responsible for oxygen-transport. The metalloenzymes constituting the second family carry out the reduction of dioxygen to water, the crucial process of the respiratory system. The last category utilizes dioxygen to functionalize substrates. These metalloenzymes have received a great deal of attention in the
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Unformatted text preview: last thirty years and are still intensively studied from both the biological and chemical perspectives. In the second part of the talk, I will present some of my previous results in mimicking metalloenzyme active sites to stabilize reactive intermediates and also in modifying cytochrome P450 BM3 with photosensitizer to generate high valent reaction species. The remaining of the talk will focus on projects to be developed in my own research lab. These projects, at the frontier of chemistry and biology, revolve around the design of new types of catalyst utilizing alternative energy sources. Tuesday, September 1, 2009, 4:30 PM Duncan Hall 135 For more information: email or phone Prof. Annalise Van Wyngarden avanwyngarden@science.sjsu.edu or 408-924-5282...
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This note was uploaded on 09/08/2010 for the course CHEM 285 at San Jose State University .

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