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Problem 9, 130C - disease It acts as an inhibitor of...

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Problem 9 (Due May 5 th ) a) You are asked to evaluate the claim that exposure of E. coli to nitrous acid has resulted in the mutation of a tRNA gly to an amber suppressor. Explain the reason that you accept or reject the possibility of the above contention. b) An antibiotic named Nopromycin appears to be effective in curing several types of venereal
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Unformatted text preview: disease. It acts as an inhibitor of bacterial translation that binds exclusively to the large subunit of E. coli ribosomes. The initiation of protein synthesis in the presence of Nopromycin results in the generation of dipeptides that remain bound to the ribosome. Suggest a mechanism of action for this antibiotic....
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