Unformatted text preview: b) In mammals, the methylation of arg residues is reversed by peptidylarginine deaminases. The reaction catalyzed by these enzymes produces a citrulline at the site of modification instead of unmethylated arginine. Specify the other product formed by the deaminase catalyzed reaction, suggest a mechanism for the transformation and stipulate the subsequent reactions that restore the side-chain to its original unmethylated form. (Hint: consider amino acid biosynthesis.)...
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This note was uploaded on 09/08/2010 for the course CHEM 130C at San Jose State.