CHEMISTRY Departmental Seminar Prof. Michael Sinensky San José State University Professor and Chair Emeritus, Dept. of Biochemistry and Molecular Biology, JH Quillen College of Medicine, East Tennessee State U. The Farnesylation Dependent Maturation of Prelamin A The assembly of lamin A into the nuclear lamina (visualized, above left, by immunofluoresence) requires a series of four sequential reactions, the first of which is farnesylation of a cysteine in a CAAX motif at the carboxyl terminus of prelamin A. The discovery of protein prenylation resulted from efforts to understand certain anomalies in the regulation of isoprenoid biosynthesis in response to
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This note was uploaded on 09/08/2010 for the course CHEM 285 at San Jose State.