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Unformatted text preview: Caloric Restriction with or without Exercise: The Fitness vs. Fatness Debate D. Enette Larson-Meyer 1,2 , Leanne Redman 1 , Leonie K. Heilbronn 3 , Corby K Martin 1 , Eric Ravussin 1 , and The Pennington CALERIE Team 1 1 Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 2 University of Wyoming, Laramie, WY 3 Garvan Institute, Sydney, Australia Abstract There is debate over the independent effects of aerobic fitness and body fatness on mortality and disease risks. PURPOSE— To determine whether a 25% energy deficit that produces equal change in body fatness leads to greater cardiometabolic benefits when aerobic exercise is included. METHODS— Thirty-six overweight participants (16 males/20 females) 39±1 y; 82±2kg; BMI=27.8 ±0.3 Kg/m 2 , mean±SEM) were randomized to one of three groups (N=12 for each) for a 6-month intervention: control (CO: weight-maintenance diet), caloric restriction (CR: 25% reduction in energy intake) or caloric restriction plus aerobic exercise (CR+EX: 12.5% reduction in energy intake plus 12.5% increase in exercise energy expenditure). Food was provided during weeks 1–12 and 22– 24. Changes in fat mass, visceral fat, VO 2peak (graded treadmill test), muscular strength (isokinetic knee extension/flexion), blood lipids, blood pressure and insulin sensitivity/secretion were compared. RESULTS— As expected, VO 2peak was significantly improved after 6 months of intervention in CR +EX only (22±5% vs. 7±5% in CR and − 5±3% in CO) whereas isokinetic muscular strength did not change. There was no difference in the losses of weight, fat mass or visceral fat and changes in systolic BP between the intervention groups. However, only CR+EX had a significant decrease in diastolic BP ( − 5±3% vs. − 2±2% in CR and − 1±2% in CO), in LDL-cholesterol ( − 13±4% vs. − 6±3% in CR and 2±4% in CO), and a significant increase in insulin sensitivity (66±22% vs. 40±20% in CR and 1±11% in CO). CONCLUSIONS— Despite similar effect on fat losses, combining CR with exercise increased aerobic fitness in parallel with improved insulin sensitivity, LDL-cholesterol and diastolic BP. The results lend support for inclusion of an exercise component in weight loss programs to improve metabolic fitness. Key Terms exercise training; maximal aerobic fitness; energy restriction; blood pressure; blood lipids Address Correspondence and Reprint Requests to: D. Enette Larson-Meyer, Ph.D., R.D, FACSM. Department 3354, 1000 E University Avenue, University of Wyoming, Laramie, WY 82071, Phone: 307-766-4378, FAX: 307-766-5686, [email protected] NIH Public Access Author Manuscript Med Sci Sports Exerc . Author manuscript; available in PMC 2010 January 13....
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- Adipose tissue, NIH-PA Author Manuscript, Med Sci Sports Exerc