Lisetal200724922749 - Review Paper Examen critique...

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162 Rev Psychiatr Neurosci 2007;32(3) © 2007 Canadian Medical Association Borderline personality disorder (BPD) is a highly prevalent psychiatric disorder that carries a severe risk factor for adolescent and young adult suicide. Relatively little research has examined its biological etiology. Differences in the volume and activity in brain structures related to emotion and impulsivity have been observed between individuals who have BPD and those who do not. The present study seeks to assess current research on the neuroanatomical differences observed between individuals with and without BPD and the genes that may play a role in the development of this disorder. Le trouble de la personnalité limite (TPL) est une affection psychiatrique très répandue qui comporte un facteur de risque grave de suicide chez les adolescents et les jeunes adultes. Il s’est fait relativement peu de recherche sur son étiologie biologique. On a observé des dif- férences entre les sujets aux prises avec le TPL et ceux qui n'en sont pas atteints au niveau du volume et de l’activité de structures du cerveau reliées à l’émotion et à l’impulsivité. La présente étude vise à évaluer la recherche courante sur les différences neuro-anatomiques observées entre des sujets avec et sans TPL, ainsi que sur les gènes qui peuvent intervenir dans le développement de ce trouble. Review Paper Examen critique Neuroimaging and genetics of borderline personality disorder: a review Eric Lis, BSc; Brian Greenfield, MD; Melissa Henry, PhD; Jean Marc Guilé, MD; Geoffrey Dougherty, MD Lis, Greenfield, Henry — Faculty of Medicine, McGill University; Greenfield, Dougherty — Montréal Children’s Hospital; Guilé — Douglas Hospital, Montréal, Que. Introduction Borderline personality disorder (BPD) is prevalent, affecting as many as 1% to 2% of the general population, 1 and this inci- dence rises as high as 15% to 20% in psychiatric settings. 2 BPD is associated with high rates of suicide — nearly all BPD pa- tients have experienced suicidal ideation and almost 10% com- mit suicide by adulthood. 3 Although psychosocial causes of BPD have been explored in many studies, relatively little data exist regarding biological causes. The neurological and genetic factors of BPD have not yet been fully explored, perhaps be- cause it is difficult to find BPD subjects to participate or be- cause the technologies used are relatively young. The study of such factors may be a key to drawing new insights into the causes, comorbidities and treatments of BPD. Methods We reviewed research on BPD, using the PubMed and PsycINFO databases. Relevant articles were found between 1980 and 2006, although we did not restrict our search to a particular time period. We selected about 49 relevant articles, using the following 3 processes: 1) we cited selected articles using a combination of the search terms “borderline person- ality disorder,” “BPD,” “MRI,” “fMRI,” “imaging,” “PET,”
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Lisetal200724922749 - Review Paper Examen critique...

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