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Presentation1 - Chapter 5 DNA, Dollars, and Drugs Epoetin...

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Chapter 5 DNA, Dollars, and Drugs
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Epoetin Alpha Epoetin Alpha- Amgen, and Genetics institute both developed a recombinant form of EPO. EPO is a protein that stimulates red blood cell production. Recombinant EPO is used for by patients undergoing kidney dialysis. Amgen won the court battle with Genetics Institute. EPO is now worth 2 billion dollars. Amgen is today the biggest player in the biotech world, worth 64 billion dollars.
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MAb Monoclonal Antibody Invented in the mid-70’s at the MCR laboratory at Cambridge University by César Milstein, and Gorges Köhler. MAbs are antibodies programmed to recognize and bind to a unique target, like tumor cells. These were hailed as the “silver bullets” that would change the face of medicine. However… they quickly ran into obstacles. Just like other products MAbs were synthesized in mice. The human immune system recognized these as foreign substances, and destroyed them before they could act on their targets. New methods have since been devised to “humanize” the MAbs, by replacing
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This note was uploaded on 04/03/2008 for the course BIO 100 taught by Professor Lutz during the Spring '08 term at MSU Bozeman.

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Presentation1 - Chapter 5 DNA, Dollars, and Drugs Epoetin...

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