sp_lect9 - Tuesday, February 13, 2007 Sacromere Structure...

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Tuesday, February 13, 2007 Sacromere Structure Fig 13.3a A band absorbs polarized light I band transmits polarized light H zone M line stabilization of thick filaments, holds them in position Fig 13.6 I band shortens H zone shortens A band remains the same Thin – actin Thick – myosin Actin has myosin-binding sites Thin filament: Thick filament: long myosin molecule with an intertwined tail and a heads (w/ actin binding site and ATPase site) Two heads – tail – two heads Thin filaments are pulled towards the thick filaments Thick filaments are stabilized by Titin at ends of sacromere Crossbridge cycle Fig 13.7 1. Binding of myosin to actin 2. Power stroke 3. Rigor (myosin in low energy form) 4. Unbinding of myosin and actin 5. Cocking of the myosin head (myosin in high energy form) – ATP is hydrolyzed Rigor mortis – result of ADP Thin filament Fig 13.9 Two strings of actin molecules with tropomyosin and troponin complexes and Ca++ binding sites Ca++ triggers initiation of contraction by binding to Troponin complexes and exposing
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This note was uploaded on 04/03/2008 for the course CELL BIO & 356 taught by Professor Merrill during the Spring '08 term at Rutgers.

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sp_lect9 - Tuesday, February 13, 2007 Sacromere Structure...

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