sp_lect5 - Tuesday Selected Members of the classes of...

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Tuesday, January 30, 2007 Selected Members of the classes of neurotransmitters Table 9.1 Fast synaptic response – Ionotropic receptor / ion channel Fig 9.3a Fast response: neurotransmitter binds, opens receptor / gate. Usually for K+ movement. One receptor activates only one gate (itself). 10-15 milliseconds. Slow synaptic response – Metabotropic receptor (Channel binds G-protein) Fig 9.3b Slow response, direct coupling. One receptor can activate many g-proteins. Slower because it’s indirect. Slow synaptic response – Metabotropic receptor (Channel binds 2 nd messenger) Fig 9.3c Gate activated by second messenger binding. Receptor – G protein – activates/deactivates enzyme – 2 nd messenger(s) – effect on channel. Slow synaptic response – Metabotropic receptor (Channel is phosphorylated) Fig 9.4b Long delay. Same as above + cAMP – Protein kinase A – phosphorylate channel. Affects many channels, but takes a while.
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This note was uploaded on 04/03/2008 for the course CELL BIO & 356 taught by Professor Merrill during the Spring '08 term at Rutgers.

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sp_lect5 - Tuesday Selected Members of the classes of...

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