sp_lect2 - cAMP second messenger system Fig 5.17a...

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January 18, 2007 cAMP second messenger system: Fig 5.17a Phosphatidyl-inositol second messenger system: Fig 5.17b IP3 infuses through endo rect and ca (1) Calcium channels open, release ca. which binds to a protein kinase (to activate it) G protein control of ion channel opening/closing: Fig 5.15 Allows ions to move across the membrane - to change electrical properties of the cell. Messenger – receptor – g protein – ion gate. Changing electrical properties of cell through opening ligand-gated channels: Fig 5.12a Messenger doesn’t go through a g protein. Goes directly to gate. Changing cytosolic Ca++ levels through ligand-gated channels: Fig 5.12b Enzyme Linked Receptor: Fig 5.13 Receptor itself is a kinase (enzyme). Ex: insulin binding to tyrosine kinase receptor, which itself does something to cell. Actions of Lipophilic Messengers Fig 5.11 Some hormoes are lipid soluble. Can go directly through membrane. Binds to receptor inside of cell, possibly inside of nucleus.
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sp_lect2 - cAMP second messenger system Fig 5.17a...

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