Problem 10,135

Problem 10,135 - increases. Specify the effect of this...

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Problem 10 (Due May 12 th ) a) Anaplerotic reactions permit the TCA cycle to supply intermediates to biosynthetic pathways while maintaining the proper levels of cycle intermediates. Show the sequence of reactions that result in the net synthesis of citrate from pyruvate (one of which is a prominent example of an anaplerotic reaction). b)When the rate at which the TCA cycle operates slows, the concentration of acetyl CoA
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Unformatted text preview: increases. Specify the effect of this metabolite on the activity of pyruvate carboxylase, and discuss the metabolic advantages this affords the cell if i) the TCA cycle is slowed due to depletion of intermediates, or ii) the cycle is slowed due to an abundant energy supply (i.e., high [ATP], [NADH])....
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