oh - It is important to note that halogens are more...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
It is important to note that halogens are more electronegative than carbon. The C-X bond is therefore polar, with the carbon atom containing a slight positive charge and the halogen a negative charge. This creates a substantial dipole moment and implies that the alkyl halide C-X carbon atom should behave as an electrophile in polar reactions. Griseofulvin is used to treat skin infections such as jock itch, athlete's foot, and ringworm; and fungal infections of the scalp, fingernails, and toenails. Skip Depending on the relative timing of these events, different mechanisms are possible: Loss of the LG to form a carbocation, removal of H+ and formation of C=C bond : E1 reaction Simultaneous H+ removal, C=C bond formation and loss of the LG : E2 reaction Removal of H+ to form a carbanion, loss of the LG and formation of C=C bond (E1cb reaction) Termination: In this reaction, the halide radical will attack primarily in the place that will yield the most substituted alkyl radical. This is because more highly substituted radicals are more
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 09/07/2010 for the course CHEM CH 2123 taught by Professor Heemoonpark during the Summer '10 term at Austin Community College.

Page1 / 3

oh - It is important to note that halogens are more...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online