Midterm 2_10WhKey

Midterm 2_10WhKey - Name White Key Last First BIS102-002...

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Name White Key BIS102-002, Spring ‘10, Page 1 of 8 Last, First C. S. Gasser © 2010, Charles S. Gasser BioSci 102-002 May. 18, 2010, Second Midterm Instructions: There are eight pages in this exam including the cover sheet, please count them before you start to make sure all are present. Write your name on each page of the exam. Write your answers in the space provided below each question. If you need more space use the back of the page and indicate clearly that you have continued your answer on the back. Do not use additional paper. For calculation problems a clear line of calculations leading to your final answer must be shown to obtain full credit. Use the following pK a values for the exam. Amino Acid α -NH 2 α -COOH R-group log 1.0 = 0.00 Ala, Gly, Ile, Leu, Val 9.7 2.3 log 1.5 = 0.18 Asn, Gln 9.0 2.1 log 2.0 = 0.30 Met, Ser, Trp 9.3 2.3 log 2.5 = 0.40 Phe 9.1 1.8 log 3.0 = 0.48 Pro 10.6 2.0 log 3.5 = 0.54 Thr 10.4 2.6 log 4.0 = 0.60 Asp 9.8 2.1 3.9 log 4.5 = 0.65 Glu 9.7 2.2 4.2 log 5.0 = 0.70 His 9.2 1.8 6.0 log 5.5 = 0.74 Cys 10.8 1.8 8.3 log 6.0 = 0.78 Tyr 9.1 2.2 10.0 log 6.5 = 0.81 Lys 9.0 2.2 10.5 log 7.0 = 0.85 Arg 9.0 2.2 12.5 log 7.5 = 0.88 log 8.0 = 0.90 R = 8.3 X 10 -3 kJ/K•mol log 8.5 = 0.93 log 9.0 = 0.95 25°C = 298K log 9.5 = 0.98 log 10.0 = 1.00
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Name White Key BIS102-002, Spring ‘10, Page 2 of 8 Last, First C. S. Gasser © 2010, Charles S. Gasser Question Value Score 1 20 2 26 3 18 4 21 5 36 6 15 7 14 Total 150 1. (20) In the space below, draw the complete chemical structure of 1-stearoyl, 2-oleoyl phosphatidyl serine. Draw it in the form that would predominate at pH 7. P O O - O CH 2 HC H 2 C O (CH 2 ) 16 CH 3 C O O CH 2 HC CO 2 - H N + 3 O (CH 2 ) 7 CH 3 C O (CH 2 ) 7 H C H C
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Name White Key BIS102-002, Spring ‘10, Page 3 of 8 Last, First C. S. Gasser © 2010, Charles S. Gasser 2. (26) A sample of human hemoglobin (Hb) was assayed for oxygen binding in the presence of equimolar BPG in a solution at pH 7. It was found to bind oxygen according to the equation Y = P O 2 2 P O 2 2 + P 50 2 where P 50 = 30 mm Hg. a) (16) If P O2 in the lungs was 90 mm Hg and in the tissues was 35 mm Hg, how many moles of O 2 would be delivered to the tissues through a single cycle of one mole of this Hb from the lungs to the tissues (assume pH and P CO2 are constant in the blood of this individual)? First determine what fraction of binding sites delivered O 2 . Lungs: Y = 90 2 90 2 + 30 2 = 0.90 Tissues: Y = 35 2 35 2 + 30 2 = 0.58 Binding sites delivering O 2 = 0.90 – 0.58 = 0.32 4 binding sites/Hb -> 0.32 • 4 moles of binding sites = 1.28 moles of O 2 delivered b) (10) In fact, pH and P CO2 do vary in the blood. So the real situation in this individual is such that the P 50 of the Hb in the lungs is 30 mm Hg, but in the tissues it is 40 mm Hg (due to lower pH and higher P CO2 ). The P O2 in tissues and lungs is as in part a). The exponent does not change. Under these conditions how many moles of O 2 would be delivered to the tissues by a single cycle of one mole of this Hb?
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Midterm 2_10WhKey - Name White Key Last First BIS102-002...

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