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CBN Lecture 8 - Lecture#8 Connective Tissue Matrix...

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Lecture #8 12/12/07 Connective Tissue Matrix composition determine function Composition of Extracellular matrix FIBROUS MATRIX A. Collagen – Tensile Strength a. Most common protein in the body made by fibroblast i. Made by many other Epith, Muscle, Bone, etc. b. Made of 3 polypeptides wrapped in 3-helix structure i. Called collagen FIBRILS – small ii. Align fibrils into large FIBERS (Hinted at multiple choice) __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ Whole thing = a FIBER Each individual row = a FIBRIL By TEM = banded structure = 64 nm periodicity Tendon aligned along long axis Dermis alternating layers (think ply wood) Collagen Type I Collagen Type IV – Basement Membrane (UNIQUE) does not line up to form fibers or periodicity Forms Hairnet-like structure 16-20 Collagens c. Cells make Collagenase – Remodel & Repair Tissues or Developmental Bio i. Scar Tissue (Overproduction of Collagen) B. Fibronectin (FN) a. Dimer 460 kilo Dalton b. FN – dual function i. Binds other matrix proteins (Collagen, Fibrin (clotting), heparin (GAG) [Allows
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