lecture note 12 - DNA Structure and Replication Discovery...

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1 DNA Structure and Replication Discovery of DNA as the Genetic Material DNA Structure Elucidation and Details DNA Replication Process DNA Repair Mechanisms K. Sathasivan Griffith’s Experiments Figure 11.2 Genetic Transformation by DNA (Part 1) Avery, McLeod and McCarty, 1944 – Transformation Experiment Figure 11.2 Genetic Transformation by DNA (Part 2) Hershey and Chase, 1952 – Phage Experiment Figure 11.3 Bacteriophage T2: Reproduction Cycle
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2 Figure 11.4 The Hershey–Chase Experiment (Part 1) Figure 11.4 The Hershey–Chase Experiment (Part 2) Figure 11.5 Transfection in Eukaryotic Cells Evidence so far Griffith’s experiment Mouse and R/S strain Avery and his group Transformation Hershey and Chase Phage with 32 P and 35 S DNA can transform eukaryotic cells Charagaff’s rule % of A=T; % of G=C Elucidation of DNA Structure Figure 3.23 Nucleotides Have Three Components repeat fig 3.23 here
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3 5' end Deoxyribose (a 5-carbon sugar) Phosphate Adenine (A) Guanine (G) Purines (double-ring structures) Fig. 14-4, p. 281 3' end Thymine (T) Cytosine (C) Pyrimidines (single-ring structures) DNA X-ray Diffraction Figure 11.7 Chargaff’s Rule
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4 2 nm 5' end Distance between each pair of bases = 0.34 nm Eh f l l ti tf Fig. 14-6, p. 283 Each full twist of the DNA double helix = 3.4 nm Phosphate group 5-carbon sugar deoxyribose) Nitrogenous base (guanine) Hydrogen bond 5' end
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This note was uploaded on 09/12/2010 for the course BIO 311C taught by Professor Sathasivan during the Fall '10 term at Austin Community College.

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lecture note 12 - DNA Structure and Replication Discovery...

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