04DNARepFQ - 8. How do mutations arise? Is there any way...

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Focus Questions: DNA Replication 1.   What is the mechanism of DNA replication?  Why do we call this mechanism semiconservative? 2.  What are the basic requirements for DNA replication?  What is the function of each? 3.  What is the essential activity of DNA Polymerases?  What requirements and features of their  action are important to their function?  What additional activities do some these enzymes exhibit? 4. How does the structure of DNA and the action of the DNA Polymerases determine how  replication proceeds?  What are the leading and lagging strands?  How is synthesis different on  these two strands? 5.  What kinds of enzymes are needed to prime synthesis of DNA?  Why are these enzymes needed? 6.  What is the replication fork?  What kinds of activities should we expect to be found at the fork? 7.  How are all of the enzymes involved in replication actually organized in the cell?
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Unformatted text preview: 8. How do mutations arise? Is there any way the frequency of mutations can be increased? What is the difference between a point mutation and a chromosomal mutation? 9. Can cells respond to DNA damage? How do they respond? What happens when these systems are not functional? 10. What are the consequences of mutations for human health? Are all tissues affected in the same way? 11. How are mutations related to cancer? Do all genes that affect cancer act in the same way? If there are differences, what is the affect of these differences? David H. Bos (2008). This material can be used for non-profit educational purposes, if properly attributed. All other uses are prohibited unless written permission is granted....
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This note was uploaded on 09/12/2010 for the course BIOL 111 taught by Professor Dr.zielinski during the Spring '08 term at Purdue University-West Lafayette.

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