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Lec 19 - Muscle III - Lecture 19 Muscle III Reading Chapter...

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Lecture 19: Muscle III Reading: Chapter 5, pages: 229 – 235 First Edition: Chapter 6, 231 – 233, 239 - 243 Lecture Outline Cardiac Muscle Contraction Smooth Muscle Contraction
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Cardiac Muscle
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Cardiac Muscle Uninucleated, short and branched cells. Intercalcated discs - Desmosomes and Gap junctions (electrical synapse). Contractile proteins: Myosin, actin, troponin and tropomyosin. Oxidative phosphorylation of lipids and carbohydrates solely provides energy.
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Cardiac Muscle Contd….. Pacemaker cells have an unstable membrane potential of –60mV. Pace maker cells have leaky membrane –Na + and K + channels. No hyperpolarization. Role of nervous and endocrine systems.
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-60 -40 -20 0 20 Membrane Potential (mV) (I f ) Na + channels open T - Ca ++ channels open L - Ca ++ channels open L - Ca ++ channels close, K + channels open K + channels close Pacemaker Action Potential
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Excitation-Contraction Coupling in Cardiac Muscle
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1. Na + Channels open – Na + influx.
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