Lec3 - Metabolism II - Lecture 3 - Metabolism II Reading:...

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Lecture 3 - Metabolism II Reading: Chapter 2. pp 35 – 42, 60 - 64 Lecture Outline: Role of Enzymes in Metabolism Role of Hormones in Metabolism Integration of Metabolic Pathways Substrate Preference during energy demand
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Role of Hormones and Enzymes in Metabolism
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How is energy released and utilized from food molecules? Hormones and enzymes regulate metabolism by determining: 1. When 2. Where 3. Which Organic molecules (carbohydrate, fat or protein) are utilized as the source of fuel. Hormones act at the broader level of regulation. Hormones regulate enzyme activity. Enzymes regulate specific biochemical steps in the pathway of energy generation.
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Enzymes are catalysts only. Enzymes are substrate specific. Substrate orientation/presentation. Weakening the bonds in substrate molecule. Providing a conducive micro-environment. Enzyme Action Enzymes lower the activational energy requirement by:
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Species Variation In Enzyme Activity Is Due To Variation In Enzyme Structure.
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Fig 2.17 Species variation in the structure of Lactate Dehydrogenase (LDH) affects enzyme activity.
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Enzymes are Reaction Regulators.
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Glycolysis Figure 2.28
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Phosphorylation may lead to activation or inactivation of enzymes.
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Phosphorylated Phosphorylated Glycogen synthesis inhibited Glycogen breakdown stimulated Fig 2.26
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specific. Example: Only liver contains
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Lec3 - Metabolism II - Lecture 3 - Metabolism II Reading:...

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