Lec12 - Neurobiology II - Lecture 12 Nervous System II...

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Lecture 12 Nervous System II Reading: Chapter 4, pp. 146 - 154 Lecture Outline: Resting Membrane Potential Graded Potentials Hyperpolarization Depolarization Summation of Graded Potentials Origination of Axonal Signal
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Ionic Environment Inside Neuron vs. Outside Neuron Na + more K + less Cl - more Proteins - less Result: e + charge Na+ less K+ more Cl - less Proteins - more Result: e - charge Inside neurons: Anions - proteins, amino acids, sulfate, and phosphate , and cation - K + are more concentrated. Outside neurons: Anion Cl and cation Na + are more concentrated. This results in separation of charge: Net -ive charge inside and net +ive charge outside.
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Ionic charge difference across membrane is measured as electrical charge in mV. Membrane Potential – The difference in charge between outside and inside.
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Resting Membrane Potential At rest an unstimulated neuron usually has a resting membrane potential of about 70mV. Outside charge is arbitrarily defined as 0. Since the inside is negative relative to the Outside , therefore, resting membrane potential is about –70mV.
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Resting potential is
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Lec12 - Neurobiology II - Lecture 12 Nervous System II...

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