Lec18 - Muscle II - Lecture 18: Muscle II Reading: Chapter...

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Unformatted text preview: Lecture 18: Muscle II Reading: Chapter 5, pp 224 – 230 First Edition: Chapter 6, 225 - 232 Lecture Outline • Neuromuscular junction • T-Tubule System and Sarcoplasmic Reticulum • Excitation – Contraction Coupling • Contraction of Muscle Bundle Summation of Contraction • Temporal summation • Spatial Summation Motor Units and Motor Unit Recruitment Neuromuscular Junction: Motor Endplate Motor neuron Acetylcholine Sarcolemma Nicotinic receptors Action potential Na + Voltage-gated Ca ++ Channels Ca ++ Ca ++ Ca ++ Ca ++ influx triggers two events: 1.Vesicle transport. 2.Vesicle fusion. 1. 2. Ca ++ Ca ++ Ca ++ Role of Ca ++ in neurotransmitter release at synapse Muscle fibers respond to the excitation signal (acetylcholine) with a rapid depolarization which is coupled with its physiological response: Muscle Contraction. Excitation – Contraction Coupling Ion Channels Involved in Excitation – Contraction Coupling 5 K + channel (DHPR receptor) (RyR receptor) T Tubules and Sarcoplasmic Reticulum 1.Release of Acetylcholine at neuro- muscular junction. Acetylcholine binds to Nicotinic Receptor Na+...
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This note was uploaded on 09/12/2010 for the course BIOLOGY 225 taught by Professor Pavgi during the Winter '10 term at University of Michigan.

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Lec18 - Muscle II - Lecture 18: Muscle II Reading: Chapter...

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