exam_1_2009_solutions

exam_1_2009_solutions - BIOL 4087 Section 3 Fall 2009 Exam...

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1 BIOL 4087 Section 3 Fall 2009 Exam 1 Sept. 24 2009 Part 1: Multiple Choice. Pick the best answer: 5 points each 1. Which of the following amino acid side chains is most likely to be found near the surface of a protein in water? a) Asp b) Leu c) Phe d) Pro 2) Hemoglobin contains four subunits. The arrangement between them constitutes the protein’s a) Primary structure b) Secondary structure c) Tertiary structure d) Quaternary structure 3) RNA sequences can be analyzed for the location of hairpin (also called “stem - loop”) f olds. Which of the following sequences could form a mini-hairpin? a) AGGUUUCCU b) AGGUUUGGA c) AGGUUUAGG d) AAAAAAAAA 4) Phe is replaced in the polypeptide sequence nMet-Gly-Lys-Glu-Ala-Leu-Leu-Lys- Asp-Phe-Asn by amino acid X, and the total charge is reduced by 1 at pH 13, but remains the same as it was for the original peptide at pH 7 and at pH 2. The new amino acid is a) Ile b) Arg c) Tyr d) It’s impossible to say from this information
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2 5) You give a spectroscopist four peptides and ask her to tell you how much you have of each. She tells you that she can only see UV absorbance coming from one of them. Which one can she see? a) Met-Glu-Gly-Ala-Ala-Thr-Gly-Arg-Arg-Thr-Ala-Thr-Pro-Gln-Gln-Lys-Lys-Gly b) Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly- c) Trp-Trp-Trp-Trp-Trp-Trp-Trp-Trp-Trp-Trp d) Gly-Gly-Leu-Gly-Leu-Gly-Leu-Gly-Leu-Gly-Leu 6) In the reaction below, the enzyme uses two strategically placed aspartate residues to coordinate two magnesium ions. The two positively charged magnesiums sit near the negatively charged phosphate and the nucleophilic 3’ OH . The enzyme is a) Hemoglobin b) Lysozyme c) RNA polymerase d) DNA polymerase e) Could be RNA or DNA polymerase
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3 7) An enzyme is in an equilibrium between a “T” state and an “R” state. The free energy of the R state is 8.19 Kcal/mole greater than that of the T state.
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exam_1_2009_solutions - BIOL 4087 Section 3 Fall 2009 Exam...

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