{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

Ch2-3 - :TheCase ofMyoglobin Recall Backbone contains...

Info icon This preview shows pages 1–8. Sign up to view the full content.

View Full Document Right Arrow Icon
Protein Tertiary Structure: The Case  of Myoglobin Yellow=“hydrophobic” Blue=“polar” Recall: Backbone contains polar (CO and NH) groups Heme group helps to coordinate iron: 2 histidine residues in core 70% of main chain is alpha helices Max Perutz
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Proteins that lie  within cell  membranes adjust  to a hydrophobic  environment  CD4 Protein contains 4 domains of 100 aa each
Image of page 2
Quaternary Structure λ  cro protein Α2 β 2 tetramer of human hemoglobin Coat of Rhinovirus
Image of page 3

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Amino Acid Sequence is Determined by  Genes (DNA Sequence) Sequence Determines: Function Structure Pathologies Evolutionary History Bovine Insulin sequenced by Frederick Sanger in 1953 (1st of 100,00!)
Image of page 4
Disulfide Bonds Normally are Formed  Between Cysteines Under Oxidizing  (Extracellular) Conditions Collagen fibers (connective tissues) & fibrin blood clots have nondisulfide cross links
Image of page 5

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Anfinsen Experiment: Denaturing and Refolding a Protein Reversible!
Image of page 6
Misfolding  of Proteins
Image of page 7

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 8
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern