Ch2-3 - ProteinTertiaryStructure:TheCase ofMyoglobin...

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Protein Tertiary Structure: The Case  of Myoglobin Yellow=“hydrophobic” Blue=“polar” Recall: Backbone contains polar (CO and NH) groups Heme group helps to coordinate iron: 2 histidine residues in core 70% of main chain is alpha helices Max Perutz
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Proteins that lie  within cell  membranes adjust  to a hydrophobic  environment  CD4 Protein contains 4 domains of 100 aa each
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Quaternary Structure λ  cro protein Α2 β 2 tetramer of human hemoglobin Coat of Rhinovirus
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Amino Acid Sequence is Determined by  Genes (DNA Sequence) Sequence Determines: Function Structure Pathologies Evolutionary History Bovine Insulin sequenced by Frederick Sanger in 1953 (1st of 100,00!)
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Disulfide Bonds Normally are Formed  Between Cysteines Under Oxidizing  (Extracellular) Conditions Collagen fibers (connective tissues) & fibrin blood clots have nondisulfide cross links
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Anfinsen Experiment: Denaturing and Refolding a Protein Reversible!
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Ch2-3 - ProteinTertiaryStructure:TheCase ofMyoglobin...

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