Ch2-1 - (Aliphatic Amino Acids) thioether Extra chiral...

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BIOL 4087, Chapter 2
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The Central Dogma DNA RNA Protein
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Properties of Proteins l Linear Chains of Amino Acids l Many Chemical Groups Perform Many Functions l Interact to Form Assemblies l Rigidity and Flexibility “Structure dictates function”-Stryer “Structure is Form, Dynamics is Function”- Schachman lactoferrin Insect flight tissue
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Proteins are Composed of L-amino  acids The alpha carbon is a chiral group, all proteins contain S (rather than R) configuration in L amino acid
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Amino Acids are Classified According to Their Physico- l Shape l Charge l Hydrogen-bonding capacity l Hydrophobic character l Chemical reactivity These properties determine the form and function of protein built from an aa sequence
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The Simplest Amino Acids “R=“ (achiral)
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Amino Acids  Containing  Hydrocarbon  Side Chains 
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Unformatted text preview: (Aliphatic Amino Acids) thioether Extra chiral center These produce hydrophobicity Proline is the Most Conformationally Restricted Amino Acid Aromatic Amino Acids Reactive OH Polar NH Purely Hydroph obic Beers Law: A= cl, =extinction coefficient, c=molar concentration, l=path length Hydroxyl Containing Amino Acids are reactive and hydrophilic Cysteine Contains Sulfhydryl Groups and Can Form Disulfide Bonds (note similarity to alanine & isoleucine) (similarity to serine) The Basic Amino Acids are Positively Charged at Neutral pH pK =6 pKa~ 6 Amino Acids With Carboxylates and Carboxamides Negatively charged Neutral 7 Sidechains and 2 Termini Contain Ionizable groups...
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This note was uploaded on 09/13/2010 for the course BIOL 4087 taught by Professor Waldrop during the Spring '08 term at LSU.

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Ch2-1 - (Aliphatic Amino Acids) thioether Extra chiral...

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