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Ch1 - BIOL 4087 Section 3 TTH 3.00-5.00 PM Room 155 Coates...

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BIOL 4087 Section 3 TTH 3.00-5.00 PM Room 155 Coates Hall Instructors: Fareed Aboul-ela Room 407 Choppin Hall, T 10-11, W 2.30- 3.30 Text: Biochemistry (Berg, Tymozko & Stryer) 6 th Edition
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BIOL 4087 Section 3 What is Biochemistry? Why Study Biochemistry? How to Study Biochemistry? The Scope of this Course: Syllabus
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Why Study Biochemistry? Biochemistry Reveals the Nature of Living Systems Biochemistry is Fundamental to Understanding and Advancing Medicine and Biotechnology Biochemistry is Fundamental to Human and Animal Health: Nutrition and Fitness
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Why Study Biochemistry? What makes living matter different from non- living matter? What causes diseases? How does the body react to a drug? How does the body react to food and drink? How do drugs, food, and drink affect physical health? How do drugs, food and drink affect mood and mental health (UK leaflet on Blackboard) How does exercise affect mood and energy level?
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Underlying Diversity, Biological Systems  Show Chemical Unity
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The Underlying Unity of Biological Systems  Implies a Common Ancestry
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Structural Biology Helps us to See How the  Structure of Biological Molecules Determines  Function The DNA double helix
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The Chemical Components of Deoxyribonucleic Acid (DNA) 4 Bases (nucleotides) Sugar-phosphate “backbone”
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DNA Bases Form Complementary  Interactions Hydrogen bonds: weak interactions which allow flexibility
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DNA Replication and Storage of Genetic  Information “form determines function”-Stryer “structure is form, dynamics is function”-Schachman
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What Makes Biomolecules Fold the way that They do?
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Chemical Bonds in Biochemistry: Covalent Bonds: e. g. C-C bond 1.54 Å & 85 kcal/mol Multiple Covalent bonds: e. g. C=O 175 kcal/mol Resonance structures
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Non-Covalent Interactions 1. Electrostatic 1. Hydrogen Bonding 1. van der Waals
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Electrostatic Interactions E E p = kq = kq 1 q q 2 /Dr /Dr D=dielectric constant (charge distribution of the medium)=80 for water Single charges, 3 angstroms, 1.4 Kcal/Mol (5.9 kJ/Mol) Note: Electrostatic energy ~ 1/r, Electric Field ~ 1/r 2
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Hydrogen Bonds Energy~1-3 kcal/mol Distance: 2.4-3.5 Å between heavy atoms
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van der Waals Interactions 0.5-1.0 kcal/mol (2-4 kj/mol)
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