Ch7 - Chapter 7 Hemoglobin 1. 2. 3. Allostery Cooperativity...

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Chapter 7 Hemoglobin 1. Allostery 2. Cooperativity of Oxygen Binding 3. Transport of Oxygen
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Hemoglobin Transports Oxygen Through the Blood to Tissues The heme in hemoglobin makes blood red Oxygen has limited solubility in water(blood) Hemoglobin increases the amount of oxygen that can be transported through the blood Myoglobin has much less capacity
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Binding of O2 to Hemoglobin is Cooperative (The Bohr Effect) H+ and CO2 in tissues changes the oxygen binding properties of Hb
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The Fundamental Tenet of the Concerted Model T R L = [T]/ [R] Only 2 states are present: Oxygen has higher affinity for “R” O2 + R R·O2 ] [ ] ][ [ 2 2 O R R O K R = O2 + T T·O2 ] [ ] ][ [ 2 2 O T T O K T = c = KR/KT
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The Hill Plot and the Concerted Model Hb + nO2 Hb(O2)n There are multiple (n) O2 binding sites for each Hb ] ) ( [ ] [ 2 2 n n D O Hb pO Hb K = An “all or none” model assumes a single equilibrium constant The fraction of Hb molecules with O2 bound is : ] ) ( [ ] [ ] ) ( [ 2 2 n n O Hb Hb O Hb Y + = D n D n K pO Hb Hb K pO Hb Y ] ] [ ] [ ] [ 2 2 + = By Substitution:
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Ch7 - Chapter 7 Hemoglobin 1. 2. 3. Allostery Cooperativity...

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