Ch6 - Chapter 6 Exploring Evolution Homology reveals...

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Chapter 6 Exploring Evolution: Homology Availability of databases of amino acid sequences  reveals: Similarities between 3d structures Similarities in amino acid sequence Clues to evolutionary relationships Clues to 3d structures of new proteins 35% seq. sim
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Homology is Detected Through Sequence  Alignment Both cradle a heme (iron) group Hemoglobin contains 2  α  chains and 2  β  chains
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Sequence Alignment, an Example Inserting gaps can  improve (but  complicate)  sequence  alignment A scoring system  can help assess  significance of  homology 38 matches when gap is  inserted: 25.9 % identity  for score of 355 +10 for each seq. match -25 for each gap
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Structure is more Conserved than Sequence 15.6 %  sequence  identity Actin and Hsp-70  must have a  common  ancestor 23 %  sequence  identity
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Sequence Templates Sequence Conservation Appears in Heme-Containing  Regions of Proteins
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