Chapter_12

Chapter_12 - Chapter 12 Lipids and Cell Membranes Define...

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Chapter 12 Lipids and Cell Membranes Define the Inside & Outside of Cells Selective Permeability Contain Lipids (permeability barrier) & Proteins (selective transport) Define Internal Compartments of Eucaryotic Cells
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Chapter 12 Read 326-346
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Common Features of Biological Membranes 1. Sheetlike, 2 molecules thick (60-100Å) 2. Contain lipids & proteins, some linked to carbohydrates 3. Lipids contain hydrophobic & hydrophilic moieties 4. Proteins as pumps, receptors, channels, & enzymes 5. Noncovalent, cooperative interactions 6. Always Asymmetric 7. Fluid Structures_lateral movement of components but no “flipping” 8. Electrically polarized Plasma membranes from red blood cells
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Common Features of  Membrane Lipids Polar head group and  aliphatic chain Roughly rectangular Two fatty acid chains are  parallel to each other
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Amphipathic Molecules form Characteristic Structures A Micelle ~ 20 nM diameter A Bilayer Membrane up  to millimeter Phospholipid Bilayer Bilayer is  favored over  micelle for 2  FA chains Micelles are formed by detergents  (sodium palmitate) Bilayers self assemble from Hydrophobic interactions between chains Electrostatic interactions between head  groups Chains are tightly packed to remove water  molecules Cooperativity Bilayers are extensive (up to ~107  ) Ǻ No exposed hydrocarbons
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Lipids Contain Fatty Acids A fatty acid contains hydrocarbon chain w. carboxylic acid terminal group Name: parent hydrocarbon + “oic acid”: C18  saturated chain yields octadecanoic acid, w.  1 double bond octadecenoic acid, 2 double 
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Chapter_12 - Chapter 12 Lipids and Cell Membranes Define...

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