Chapter24

Chapter24 - Chapter 24 Amino edit Biosynthesis Click toAcid...

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Click to edit Master subtitle style Chapter 24 Amino Acid Biosynthesis
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The biosynthesis of amino acids An Overview of Amino Acid Synthesis Obtain nitrogen in a easily usable form: nitrogen gas ----> ammonia Stereochemical control: controlled by aminotransferase and the role of pyridoxal phosphate; Tightly regulated: Synthesis is on only when supplies are low
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Nitrogen Fixation From nitrogen to ammonia N2 ----> NH3 microorganism --60% of Earth’s newly fixed nitrogen; Lighting and UV radiation - -15% industrial process -- 25% NH3-toxic
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Nitrogen Fixation From nitrogen to ammonia N2 + 8e- + 8H+ ----> 2NH3 + H2 electrons come from reduced ferrodoxin; N2 + 8e- + 8H+ +16ATP + 16H2O----> 2NH3 + H2 +16ADP +16Pi
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Nitrogen Fixation Reductase P-loop (conformational change)
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Ammonium ion is assimilated into an amino acid through Glu/Gln NH4+ + α -ketoglutarate + NADPH +H+ ----> glutamate + NADP+ +H2O Catabolism and synthesis
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Ammonium ion is assimilated into an amino acid through Glu/Gln Glutamate dehydrogenase NH4+ + α -ketoglutarate + NADPH +H+ ----> glutamate + NADP+ +H2O Establishes chirality of amino acid product
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Ammonium ion is assimilated into an amino acid through Glu/Gln Glutamine Synthase
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Chapter24 - Chapter 24 Amino edit Biosynthesis Click toAcid...

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