Chapter_17 - An overview of citric acid cycle oxaloacetate...

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An overview of citric acid cycle Gateway to any aerobic metabolism of any molecules that can be converted to acetyl-CoA or dicarboxylic acid; Important source of precursors for other biosynthesis, such as amino acids, nucleotide bases, cholesterol and porphyrin; Acetyl group; 2 CO2, 1 GTP; 8 e- in NADH or FADH2; oxaloacetate
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Glucose is completely oxidized through the citric acid cycle or the tricarboxylic acid (TCA) cycle or the Krebs cycle
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The formation of acetyl coA from pyruvate: the pyruvate dehydrogenase complex 4-10 md;
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The citric acid cycle oxidizes two-carbon units I. The formation of acetyl coA from pyruvate Three steps reactions; These steps must be coupled to preserve the free energy derived from the decarboxylation steps to drive the formation of NADH and acetyl-CoA.
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Pyruvate Dehydrogenase I. The formation of acetyl coA from pyruvate 1.1 Pyruvate combines with TPP and is then decarboxylated (E1) Exceptionally acidic
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Pyruvate dehydrogenase I. The formation of acetyl coA from pyruvate Step 2: the hydroxylethyl group attached to TPP is oxidized to form an acetyl group and concomitantly transferred to lipoamide (E1)
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Pyruvate dehydrogenase I. The formation of acetyl coA from pyruvate Step 3 The acetyl group is transferred from acetyllipoamide to CoA to form acetyl CoA(E2) Dihydrolipoyl transacetylase E3 modifies redox potential of FAD
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The citric acid cycle oxidizes two-carbon units Flexible linkages allow lipoamide to move between different active sites E2--trimer; E1-- α 2 β 2 tetramer; E3-- αβ dimer
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