Chapter_27

Chapter_27 - 9/14/10 Food intake and fasting • Insulin...

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Click to edit Master subtitle style 9/14/10 Chapter 27 The Integration of Metabolism
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9/14/10 Themes of Metabolism I. The basic strategy ATP as energy currency Generated by oxidation of fuel molecules-electron transport NADPH as electron donor Small set of building blocks for biosynthesis of biomolecules
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9/14/10 Themes of Metabolism I. Regulation Allosteric interactions Covalent modifications Overall enzyme levels Compartmentalization Organ specialization Control Points
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9/14/10 Some “Key Junctions” Glucose-6-phosphate Pyruvate Acetyl coA Abundant ATP, G- 6P NADPH, ribonucleotide s Trans- amination Abunda nt Ac- coA Beta oxidation
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9/14/10 Organ Specialization Brain Dependent on glucose as fuel Transported by GLUT3, low Km Muscle Glycogen provides fuel storage Alanine formed from
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9/14/10 Organ Specialization: Liver the Metabolic Hub Removes (most) glucose and monosaccharides from blood after meals Glucose 6-phosphate stored as glycogen, used for gluconeogenesis or broken into acetyl-CoA and exported as lipids/fatty acids
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Unformatted text preview: 9/14/10 Food intake and fasting • Insulin and the well-fed state – Initiation of kinase cascades – Glucokinase-a liver isozyme of hexokinase, with a low Km leads to glycogen storage – Promotes synthesis of glycogen and 9/14/10 Starvation Priority 1-glucose to the brain Priority 2-preserve amino acid in muscle 9/14/10 Ketone bodies 9/14/10 Diabetes-a disease of metabolism • Type 1-autoimmune destruction of insulin-producing cells – Excess glucagon, insufficient insulin – Failure to regulate glucose levels-increased levels of blood glucose – Breakdown of lipids, failure to utilize glucose, buildup of ketone bodies • Type 2-insulin resistance 9/14/10 Metabolism during exercise • Anaerobic metabolism – Stored ATP (5.2-3.7 mM), creatine phosphate (9.1 -2.6 mM), anaerobic glycolysis (glycogen-lactate from 1.6-8.3 mM) – Depletion of creatine phosphate and 9/14/10 Some terms from Chapter 27 • Ketone bodies...
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This note was uploaded on 09/13/2010 for the course BIOL 4087 taught by Professor Waldrop during the Spring '08 term at LSU.

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Chapter_27 - 9/14/10 Food intake and fasting • Insulin...

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