Chapter_26

Chapter_26 - HDL transports cholesterol through the body...

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Click to edit Master subtitle style Chapter 26 The Biosynthesis of Membrane Lipids and Steroids
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Reading for Chapter 26 Pages 742-752
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The Biosynthesis of membrane lipids and steroids G-3-P -----> Lysophosphatidate -------> Phosphatidate Glycerol phosphate acyltransferase
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Regulation of Cholesterol Biosynthesis Sterol regulatory binding protein/SREBP cleavage activating protein ATP hydrol + decarboxylation IP + condensation 3-hydroxy-3-methyl CoA reductase activity mRNA Translation of mRNA Degradation Phosphorylation (AMP activated)
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LDLs help transport cholesterol for incorporation into membranes 1. LDL binds receptor 2. Invagination 3. Recycling of membrane components 4. Degradation of LDL in lysosome 5. Transfer of cholesterol to internal membranes LDL receptor mRNA regulated by SREBP
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Cholesterol is transported with triacylglycerols in lipoproteins
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Unformatted text preview: HDL transports cholesterol through the body Low levels of LDL receptor lead to hypercholesterolemia and atherosclerosis HMG-CoA-reductase inhibitor Cholesterol is the source of bile salts and steroid hormones Bile salts (Solubilize dietary lipids) Cortisol: glycogen formation, degradation of fat and protein Aldosterone: blood volume and blood pressure progesterone testosterone Cytochrome P450 monooxygenase hydroxylate steroids, degrade toxins and metabolize drugs RH + O2 + NADPH + H+ ROH + H2O + NADP+ P450 contains heme prosthetic group which activates O2 Adrenoxin, reduced by NADPH, provides electron to Fe within heme Second adrenoxin provides electron to break O2 bond Integration of Metabolism (27) Integration of Metabolism (27)...
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This note was uploaded on 09/13/2010 for the course BIOL 4087 taught by Professor Waldrop during the Spring '08 term at LSU.

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Chapter_26 - HDL transports cholesterol through the body...

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