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Chapter_25 - Chapter 25 Nucleotide Biosynthesis Click to...

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Click to edit Master subtitle style Chapter 25 Nucleotide Biosynthesis
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The biosynthesis of nucleotides Incorporation into genetic material Energy currency Biosynthesis (UDP-glucose) Signal transduction (cAMP, cGMP)
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The biosynthesis of nucleotide De novo pathway for pyrimidine nucleotide synthesis Carbamoyl phosphate synthetase Glutamine as amine source
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De novo pathway for pyrimidine nucleotide synthesis Intermediates can move between active sites by channeling Intermediate diffusion prevented Labile intermediates protected 45 Ǻ 35 Ǻ
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De novo pathway for pyrimidine nucleotide synthesis Orotate acquires a ribose ring from PRPP Aspartate transcarbamoylase Pyrimidine phosphoribosyl transferase: hydrolysis of pyrophosphate Orotidylate decarboxylase
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De novo pathway for pyrimidine nucleotide synthesis UMP -->UDP ---> UTP ---> CTP UMP + ATP <=====> UDP + ADP UMP kinase XDP + YTP <=====>XTP + YDP nucleotide diphosphate kinase Phosphorylated intermediate (as for bicarbonate to carbamic acid)
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This note was uploaded on 09/13/2010 for the course BIOL 4087 taught by Professor Waldrop during the Spring '08 term at LSU.

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Chapter_25 - Chapter 25 Nucleotide Biosynthesis Click to...

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