April22nd_2008

April22nd_2008 - Human Genome Early estimates guessed that humans had over 100,000 genes owing to our complex behavior and physiology Current

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1 Behavioral Genomics Human Genome • Early estimates guessed that humans had over 100,000 genes, owing to our complex behavior and physiology • Current analyses of the human genome suggest this number is between 20,000 and 24,000 • The round-worm C. elegans has about 20,000 genes Behavioral Genomics • Human genome sequence finished in 2003 • Two competing groups – Celera Genomics (Craig Venter) – Human genome Project Human Genome • In the US, most funding for genome research comes from –NIH – Dept. of Energy Hiroshima Memorial Cenotaph Genome Sequencing Comparative Genomics • Comparative genomics is the analysis and comparison of genomes from different species. The purpose is to gain a better understanding of how species have evolved and to determine the function of genes and noncoding regions (promoters) of the genome.
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2 Important DNA Sequences • Promoter – Region of DNA that regulates gene expression • Coding region – Sequence that codes for a protein promoter coding region Promoter vs. Coding Region • Promoter is like the volume knob, determining how much a gene is expressed • Coding region is like a blue print, it contains instructions of how to build protein DNA Protein Behavior RNA “gene expression” “Central Dogma” Gene Expression • Key concept – Frequently, there is little individual variation in coding regions of genes – Promoters determining how much a gene is transcribed (turned on) often show much more variability Behavioral genomics • Coding Region – Function of protein (knock-out mice) • Gene expression – Gene expression (microarrays) – Gene-environment interactions (individual differences in promoter regions) Knockout mice • Mice that are genetically engineered to lack the function of a single gene • Generally focusing on role of the coding region, although it is possible to manipulate promoters too
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This note was uploaded on 09/13/2010 for the course PSC Psychology taught by Professor Cossowings during the Spring '08 term at UC Davis.

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April22nd_2008 - Human Genome Early estimates guessed that humans had over 100,000 genes owing to our complex behavior and physiology Current

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