May29th2008 - LTP in Hippocampus LTP occurs at several...

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1 Spatial Memory and Aging LTP in Hippocampus LTP occurs at several sites in the hippocampal formation – formed by the hippocampus , the dentate gyrus and the subiculum Figure 18.8 Long-Term Potentiation in the Hippocampus (Part 2) Long-Term Potentiation • Procedure: electrically stimulate cells that have synapses with hippocampus • Then observe population postsynaptic potentials in hippocampus • Electrical stimulation in cortex induces long-term potentiation (LTP) in hippocampus (increased PSP) Diagram of the LTP Procedure High frequency electrical stimulation of the cortex Record from cel s within the hippocampus: Subsequent cortex stimulation results in progressive increases in EPSP’s LTP and Memory LTP may be a mechanism of learning and memory formation – a kind of synaptic plasticity. LTP can be induced through a classical conditioning stimulus. Knockout mice with reduced LTP showed memory impairment.
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2 Spatial Memory in Voles • Meadow voles are polygynous. Males have large home ranges in their searches for mates • Pine voles are monogamous and have smaller home ranges Figure 17.20 Sex, Memory, and Hippocampal Size (Part 2) Figure 17.20 Sex, Memory, and Hippocampal Size (Part 3) Alternative Interpretations
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May29th2008 - LTP in Hippocampus LTP occurs at several...

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